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Identification of two novel RET kinase inhibitors through MCR-based drug discovery: Design, synthesis and evaluation
From an MCR fragment library, two novel chemical series have been developed as inhibitors of RET, which is a kinase involved in the pathology of medullary thyroid cancer (MTC). Structure activity relationship studies (SAR) identified two sub-micromolar tractable leads, 6g and 13g. 6g was confirmed t...
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| Published in: | Eur J Med Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4666024/ https://ncbi.nlm.nih.gov/pubmed/25232968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.09.023 |
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