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Opioid Bifunctional Ligands from Morphine and the Opioid Pharmacophore Dmt-Tic
Bifunctional ligands containing an ester linkage between morphine and the δ-selective pharmacophore Dmt-Tic were synthesized, and their binding affinity and functional bioactivity at the μ, δ and κ opioid receptors determined. Bifunctional ligands containing or not a spacer of β-alanine between the...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035428/ https://ncbi.nlm.nih.gov/pubmed/21216504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2010.12.001 |
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