Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore

[Image: see text] Based on a renewed importance recently attributed to bi- or multifunctional opioids, we report the synthesis and pharmacological evaluation of some analogues derived from our lead μ agonist/δ antagonist, H-Dmt-Tic-Gly-NH-Bzl (Dmt = 2′,6′-dimethyl-l-tyrosine, Tic = 1,2,3,4-tetrahydr...

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Egile Nagusiak: Balboni, Gianfranco, Salvadori, Severo, Trapella, Claudio, Knapp, Brian I., Bidlack, Jean M., Lazarus, Lawrence H., Peng, Xuemei, Neumeyer, John L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2009
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843921/
https://ncbi.nlm.nih.gov/pubmed/20352071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn900025j
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