Modulation of Silent and Constitutively Active Nociceptin/Orphanin FQ Receptors by Potent Receptor Antagonists and Na(+) Ions in Rat Sympathetic Neurons

Por Mahmoud, Saifeldin, Margas, Wojciech, Trapella, Claudio, Caló, Girolamo, Ruiz-Velasco, Victor
Publicado em 2010

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism

Por Viaro, Riccardo, Sanchez-Pernaute, Rosario, Marti, Matteo, Trapella, Claudio, Isacson, Ole, Morari, Michele
Publicado em 2008

Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells

Por Bortolotti, Daria, LeMaoult, Joel, Trapella, Claudio, Di Luca, Dario, Carosella, Edgardo D., Rizzo, Roberta
Publicado no Infect Immun (2015)

A new opioid designed multiple ligand derived from the μ opioid agonist endomorphin-2 and the δ opioid antagonist pharmacophore Dmt-Tic

Por Salvadori, Severo, Trapella, Claudio, Fiorini, Stella, Negri, Lucia, Lattanzi, Roberta, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Balboni, Gianfranco
Publicado em 2007

New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores

Por Neumeyer, John L., Peng, Xuemei, Knapp, Brian I., Bidlack, Jean M., Lazarus, Lawrence H., Salvadori, Severo, Trapella, Claudio, Balboni, Gianfranco
Publicado em 2006

Further Studies on Lead Compounds Containing the Opioid Pharmacophore Dmt-Tic

Por Balboni, Gianfranco, Fiorini, Stella, Baldisserotto, Anna, Trapella, Claudio, Sasaki, Yusuke, Ambo, Akihiro, Marczak, Ewa D., Lazarus, Lawrence H., Salvadori, Severo
Publicado em 2008

Evolution of the Bifunctional Lead μ Agonist/δ Antagonist Containing the 2′,6′-Dimethyl-l-tyrosine−1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (Dmt−Tic) Opioid Pharmacophore...

Por Balboni, Gianfranco, Salvadori, Severo, Trapella, Claudio, Knapp, Brian I., Bidlack, Jean M., Lazarus, Lawrence H., Peng, Xuemei, Neumeyer, John L.
Publicado em 2009

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative

Por Ruzza, Chiara, Rizzi, Anna, Malfacini, Davide, Pulga, Alice, Pacifico, Salvatore, Salvadori, Severo, Trapella, Claudio, Reinscheid, Rainer K, Calo, Girolamo, Guerrini, Remo
Publicado no Pharmacol Res Perspect (2015)

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

Por Rizzi, Anna, Cerlesi, Maria Camilla, Ruzza, Chiara, Malfacini, Davide, Ferrari, Federica, Bianco, Sara, Costa, Tommaso, Guerrini, Remo, Trapella, Claudio, Calo', Girolamo
Publicado no Pharmacol Res Perspect (2016)

Role of Benzimidazole (Bid) in the δ Opioid Agonist Pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502)

Por Salvadori, Severo, Fiorini, Stella, Trapella, Claudio, Porreca, Frank, Davis, Peg, Sasaki^, Yusuke, Ambo, Akihiro, Ewa, D Marczak, Lazarus, Lawrence H., Balboni, Gianfranco
Publicado em 2007

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

Por Guerrini, Remo, Camarda, Valeria, Trapella, Claudio, Calo’, Girolamo, Rizzi, Anna, Ruzza, Chiara, Fiorini, Stella, Marzola, Erika, Reinscheid, Rainer K., Regoli, Domenico, Salvadori, Severo
Publicado em 2009

Further studies at neuropeptide S position 5: discovery of novel neuropeptide S receptor antagonists

Por Guerrini, Remo, Camarda, Valeria, Trapella, Claudio, Calo’, Girolamo, Rizzi, Anna, Ruzza, Chiara, Fiorini, Stella, Marzola, Erika, Reinscheid, Rainer K., Regoli, Domenico, Salvadori, Severo
Publicado em 2009

Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore

Por Balboni, Gianfranco, Onnis, Valentina, Congiu, Cenzo, Zotti, Margherita, Sasaki, Yusuke, Ambo, Akihiro, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Trapella, Claudio, Salvadori, Severo
Publicado em 2006

Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands

Por Pacifico, Salvatore, Carotenuto, Alfonso, Brancaccio, Diego, Novellino, Ettore, Marzola, Erika, Ferrari, Federica, Cerlesi, Maria Camilla, Trapella, Claudio, Preti, Delia, Salvadori, Severo, Calò, Girolamo, Guerrini, Remo
Publicado no Sci Rep (2017)

Further Studies on the Effect of Lysine at the C-Terminus of the Dmt-Tic Opioid Pharmacophore

Por Balboni, Gianfranco, Onnis, Valentina, Congiu, Cenzo, Zotti, Margherita, Sasaki, Yusuke, Ambo, Akihiro, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Lazzari, Ilaria, Trapella, Claudio, Salvadori, Severo
Publicado em 2007

Synthesis and separation of the enantiomers of the Neuropeptide S receptor antagonist (9R/S)-3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzyla...

Por Trapella, Claudio, Pela', Michela, Zoppo, Luisa Del, Calo', Girolamo, Camarda, Valeria, Ruzza, Chiara, Cavazzini, Alberto, Costa, Valentina, Bertolasi, Valerio, Reinscheid, Rainer K., Salvadori, Severo, Guerrini, Remo
Publicado em 2011

The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor

Por Miller, Rebecca L., Thompson, Aaron A., Trapella, Claudio, Guerrini, Remo, Malfacini, Davide, Patel, Nilkanth, Han, Gye Won, Cherezov, Vadim, Caló, Girolamo, Katritch, Vsevolod, Stevens, Raymond C.
Publicado no Structure (2015)

6-N,N-Dimethylamino-2,3-Naphthalimide a New Environment-Sensitive Fluorescent Probe in δ-Selective and μ-Selective Opioid Peptides

Por Vázquez, M. Eugenio, Blanco, Juan B., Salvadori, Severo, Trapella, Claudio, Argazzi, Roberto, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Negri, Lucia, Giannini, Elisa, Lattanzi, Roberta, Colucci, Mariantonella, Balboni, Gianfranco
Publicado em 2006

Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic

Por Thompson, Aaron A., Liu, Wei, Chun, Eugene, Katritch, Vsevolod, Wu, Huixian, Vardy, Eyal, Huang, Xi-Ping, Trapella, Claudio, Guerrini, Remo, Calo, Girolamo, Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Publicado em 2012