The importance of ligand-receptor conformational pairs in stabilization: spotlight on the N/OFQ G protein-coupled receptor

Understanding the mechanism by which ligands impact receptor conformational equilibria is key in accelerating membrane protein structural biology. In the case of G protein-coupled receptors (GPCRs) we currently pursue a brute force approach for identifying ligands that stabilize receptors and facili...

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Udgivet i:Structure
Main Authors: Miller, Rebecca L., Thompson, Aaron A., Trapella, Claudio, Guerrini, Remo, Malfacini, Davide, Patel, Nilkanth, Han, Gye Won, Cherezov, Vadim, Caló, Girolamo, Katritch, Vsevolod, Stevens, Raymond C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670589/
https://ncbi.nlm.nih.gov/pubmed/26526853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.07.024
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