Structure of the Nociceptin/Orphanin FQ Receptor in Complex with a Peptide Mimetic

Members of the Opioid Receptor (OR) family of G protein-coupled receptors (GPCRs) are found throughout the peripheral and central nervous system where they play key roles in nociception and analgesia. Unlike the classical ORs, δ–OR, κ–OR,(1) and μ-OR,(2) which were delineated by pharmacological crit...

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Autores principales: Thompson, Aaron A., Liu, Wei, Chun, Eugene, Katritch, Vsevolod, Wu, Huixian, Vardy, Eyal, Huang, Xi-Ping, Trapella, Claudio, Guerrini, Remo, Calo, Girolamo, Roth, Bryan L., Cherezov, Vadim, Stevens, Raymond C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356928/
https://ncbi.nlm.nih.gov/pubmed/22596163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11085
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