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Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain

Intracerebral administration of the excitotoxin ibotenate to newborn mice induces white-matter lesions, mimicking brain lesions that occur in human preterm infants. Nociceptin (NC), also called orphanin FQ, is the endogenous ligand of the opioid receptor-like 1 (ORL1) receptor and does not bind clas...

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書誌詳細
主要な著者: Laudenbach, Vincent, Calo, Girolamo, Guerrini, Remo, Lamboley, Géraldine, Benoist, Jean-François, Evrard, Philippe, Gressens, Pierre
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC199242/
https://ncbi.nlm.nih.gov/pubmed/11181645
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