The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo

Microvascular inflammation occurs during sepsis and the endogenous opioid-like peptide nociceptin/orphanin FQ (N/OFQ) is known to regulate inflammation. This study aimed to determine the inflammatory role of N/OFQ and its receptor NOP (ORL1) within the microcirculation, along with anti-inflammatory...

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Bibliografiske detaljer
Main Authors: Brookes, Zoë L. S., Stedman, Emily N., Brown, Nicola J., Hebbes, Christopher P., Guerrini, Remo, Calo, Girolamo, Reilly, Charles S., Lambert, David G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781147/
https://ncbi.nlm.nih.gov/pubmed/24086402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074943
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