In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

[(pF)Phe(4)Aib(7)Arg(14)Lys(15)]N/OFQ-NH(2) (UFP-112) has been designed as a novel ligand for the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) by combining into the same peptide different chemical modifications reported to increase N/OFQ potency. In vitro data obtained in the electrically s...

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Bibliographic Details
Main Authors: Rizzi, Anna, Spagnolo, Barbara, Wainford, Richard D, Fischetti, Carmela, Guerrini, Remo, Marzola, Giuliano, Baldisserotto, Anna, Salvadori, Severo, Regoli, Domenico, Kapusta, Daniel R, Calo’, Girolamo
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975813/
https://ncbi.nlm.nih.gov/pubmed/17532097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2007.04.020
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