Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

Angiotensin II type 1 receptor (AT(1)R) is the primary blood pressure regulator. AT(1)R blockers (ARBs) have been widely used in clinical settings as anti-hypertensive drugs and share a similar chemical scaffold, although even minor variations can lead to distinct therapeutic efficacies toward cardi...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Zhang, Haitao, Unal, Hamiyet, Desnoyer, Russell, Han, Gye Won, Patel, Nilkanth, Katritch, Vsevolod, Karnik, Sadashiva S., Cherezov, Vadim, Stevens, Raymond C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705918/
https://ncbi.nlm.nih.gov/pubmed/26420482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.689000
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