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Structure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor

Ligand-independent signaling by the angiotensin II type 1 receptor (AT1R) can be activated in clinical settings by mechanical stretch and autoantibodies as well as receptor mutations. Transition of the AT1R to the activated state is known to lower inverse agonistic efficacy of clinically used AT1R b...

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Publicado en:Mol Pharmacol
Main Authors: Takezako, Takanobu, Unal, Hamiyet, Karnik, Sadashiva S., Node, Koichi
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551048/
https://ncbi.nlm.nih.gov/pubmed/26121982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099176
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