Ligand-specific Conformation of Extracellular Loop-2 in the Angiotensin II Type 1 Receptor

The orientation of the second extracellular loop (ECL2) is divergent in G-protein coupled receptor (GPCR) structures determined. This discovery provoked the question, is the ECL2 conformation differentially regulated in the GPCRs that respond to diffusible ligands? We have determined the conformatio...

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Bibliografiske detaljer
Main Authors: Unal, Hamiyet, Jagannathan, Rajaganapathi, Bhat, Manjunatha B., Karnik, Sadashiva S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871501/
https://ncbi.nlm.nih.gov/pubmed/20299456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094870
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