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Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT(1)R Initiated by van der Waals Attraction
We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation generated conformational ensembles reveal propagation of structural changes through key “microswitches” within human AT(1)R bound to native hormone....
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| Publicat a: | J Chem Inf Model |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457125/ https://ncbi.nlm.nih.gov/pubmed/30608150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.8b00583 |
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