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Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT(1)R Initiated by van der Waals Attraction

We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation generated conformational ensembles reveal propagation of structural changes through key “microswitches” within human AT(1)R bound to native hormone....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Chem Inf Model
Egile Nagusiak: Singh, Khuraijam Dhanachandra, Unal, Hamiyet, Desnoyer, Russell, Karnik, Sadashiva S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457125/
https://ncbi.nlm.nih.gov/pubmed/30608150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.8b00583
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