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Mechanism of Hormone Peptide Activation of a GPCR: Angiotensin II Activated State of AT(1)R Initiated by van der Waals Attraction
We present a succession of structural changes involved in hormone peptide activation of a prototypical GPCR. Microsecond molecular dynamics simulation generated conformational ensembles reveal propagation of structural changes through key “microswitches” within human AT(1)R bound to native hormone....
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| Publicado no: | J Chem Inf Model |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457125/ https://ncbi.nlm.nih.gov/pubmed/30608150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.8b00583 |
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