Further studies at neuropeptide S position 5: discovery of novel neuropeptide S receptor antagonists

Neuropeptide S (NPS) regulates various biological functions by activating the NPS receptor (NPSR). Previous studies demonstrated that the substitution of Gly(5) with D-amino acids generates NPSR antagonists. Eleven [D-Xaa(5)]NPS derivatives were synthesized and pharmacologically tested measuring [Ca...

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Detalhes bibliográficos
Main Authors: Guerrini, Remo, Camarda, Valeria, Trapella, Claudio, Calo’, Girolamo, Rizzi, Anna, Ruzza, Chiara, Fiorini, Stella, Marzola, Erika, Reinscheid, Rainer K., Regoli, Domenico, Salvadori, Severo
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732566/
https://ncbi.nlm.nih.gov/pubmed/19473027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900604g
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