In Vitro and in Vivo Pharmacological Characterization of the Neuropeptide S Receptor Antagonist [d-Cys(tBu)(5)]Neuropeptide S

Neuropeptide S (NPS) was identified as the endogenous ligand of an orphan receptor now referred to as the NPS receptor (NPSR). In the frame of a structure-activity study performed on NPS Gly5, the NPSR ligand [d-Cys(tBu)(5)]NPS was identified. [d-Cys(tBu)(5)]NPS up to 100 μM did not stimulate calciu...

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Autori principali: Camarda, Valeria, Rizzi, Anna, Ruzza, Chiara, Zucchini, Silvia, Marzola, Giuliano, Marzola, Erika, Guerrini, Remo, Salvadori, Severo, Reinscheid, Rainer K., Regoli, Domenico, Calò, Girolamo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Pharmacology and Experimental Therapeutics 2009
Soggetti:
Neuropharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630366/
https://ncbi.nlm.nih.gov/pubmed/18971372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.143867
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