Further Studies on the Effect of Lysine at the C-Terminus of the Dmt-Tic Opioid Pharmacophore

A wide range of bioactivities are induced by Lys when introduced at the C-terminus of the δ-opioid Dmt-Tic pharmacophore through the α-amine group, such as improved δ-antagonism, and presence of μ-agonism and μ-antagonism. We report the synthesis of a new series of compounds with the general formula...

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Detalhes bibliográficos
Principais autores: Balboni, Gianfranco, Onnis, Valentina, Congiu, Cenzo, Zotti, Margherita, Sasaki, Yusuke, Ambo, Akihiro, Bryant, Sharon D., Jinsmaa, Yunden, Lazarus, Lawrence H., Lazzari, Ilaria, Trapella, Claudio, Salvadori, Severo
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377021/
https://ncbi.nlm.nih.gov/pubmed/17339114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.02.039
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