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Inhibition of the Development of Morphine Tolerance by a Potent Dual μ-/δ-Opioid Antagonist, H-Dmt-Tic-Lys-NH-CH(2)-Ph
Three analogues of the dual μ-/δ-antagonist, H-Dmt-Tic-R-NH-CH(2)-Ph (R = 1, Lys-Z; 2, Lys-Ac; 3, Lys) were examined in vivo: 1 and 2 exhibited weak bioactivity, while 3 injected intracerebroventricularly was a potent dual antagonist for morphine- and deltorphin C-induced antinociception comparable...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597683/ https://ncbi.nlm.nih.gov/pubmed/18571706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.05.008 |
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