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Inhibition of the Development of Morphine Tolerance by a Potent Dual μ-/δ-Opioid Antagonist, H-Dmt-Tic-Lys-NH-CH(2)-Ph

Three analogues of the dual μ-/δ-antagonist, H-Dmt-Tic-R-NH-CH(2)-Ph (R = 1, Lys-Z; 2, Lys-Ac; 3, Lys) were examined in vivo: 1 and 2 exhibited weak bioactivity, while 3 injected intracerebroventricularly was a potent dual antagonist for morphine- and deltorphin C-induced antinociception comparable...

詳細記述

保存先:
書誌詳細
主要な著者: Jinsmaa, Yunden, Marczak, Ewa D., Balboni, Gianfranco, Salvadori, Severo, Lazarus, Lawrence H.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597683/
https://ncbi.nlm.nih.gov/pubmed/18571706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.05.008
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