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Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism
Endogenous nociceptin/orphanin FQ (N/OFQ) inhibits the activity of dopamine neurons in the substantia nigra and affects motor behavior. In this study we investigated whether a N/OFQ receptor (NOP) antagonist, J-113397, can modify movement in naive mice and nonhuman primates and attenuate motor defic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2605654/ https://ncbi.nlm.nih.gov/pubmed/18413287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.02.011 |
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