Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism

Endogenous nociceptin/orphanin FQ (N/OFQ) inhibits the activity of dopamine neurons in the substantia nigra and affects motor behavior. In this study we investigated whether a N/OFQ receptor (NOP) antagonist, J-113397, can modify movement in naive mice and nonhuman primates and attenuate motor defic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Viaro, Riccardo, Sanchez-Pernaute, Rosario, Marti, Matteo, Trapella, Claudio, Isacson, Ole, Morari, Michele
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605654/
https://ncbi.nlm.nih.gov/pubmed/18413287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.02.011
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