Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease

The opioid-like neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are expressed in the substantia nigra (SN), a brain area containing dopamine neurons that degenerate in Parkinson's disease. Endogenous N/OFQ facilitates nigral glutamate release and inhibits nigrostriatal dopami...

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Vydáno v:J Neurosci
Hlavní autoři: Marti, Matteo, Mela, Flora, Fantin, Martina, Zucchini, Silvia, Brown, Jeffrey M., Witta, Jassir, Di Benedetto, Manuela, Buzas, Beata, Reinscheid, Rainer K., Salvadori, Severo, Guerrini, Remo, Romualdi, Patrizia, Candeletti, Sanzio, Simonato, Michele, Cox, Brian M., Morari, Michele
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725738/
https://ncbi.nlm.nih.gov/pubmed/16237164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2546-05.2005
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