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Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease
To investigate whether the endogenous neuropeptide nociceptin/orphanin FQ (N/OFQ) contributes to the death of dopamine neurons in Parkinson's disease, we undertook a genetic and a pharmacological approach using NOP receptor knockout (NOP(−/−)) mice, and the selective and potent small molecule N...
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| Publicado no: | Neurobiol Dis |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567676/ https://ncbi.nlm.nih.gov/pubmed/26804029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.01.016 |
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