Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Agonists

Activation of brain nociceptin/orphanin FQ (NOP) receptors leads to attenuation of μ-opioid receptor (MOP receptor)-mediated antinociception. Buprenorphine, a high-affinity partial MOP receptor agonist also binds to NOP receptors with 80 nM affinity. The buprenorphine-induced inverted U-shaped dose-...

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Autors principals: Khroyan, Taline V., Polgar, Willma E., Jiang, Faming, Zaveri, Nurulain T., Toll, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Behavioral Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784721/
https://ncbi.nlm.nih.gov/pubmed/19713488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.156711
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