Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/μ-Opioid Receptor Ligands: Implications for Therapeutic Applications

The nociceptin receptor (NOPr), a member of the opioid receptor family, is a target for the treatment of pain and drug abuse. Nociceptin/orphanin FQ (N/OFQ), the endogenous peptide for NOPr, not only modulates opioid antinociception, but also blocks the rewarding effects of several abused drugs, suc...

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Hlavní autoři: Toll, Lawrence, Khroyan, Taline V., Polgar, Willma E., Jiang, Faming, Olsen, Cris, Zaveri, Nurulain T.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Behavioral Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784720/
https://ncbi.nlm.nih.gov/pubmed/19773529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.157446
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