Structure-Based Virtual Screening of the Nociceptin Receptor: Hybrid Docking and Shape-Based Approaches for Improved Hit Identification

Por Daga, Pankaj R., Polgar, Willma E., Zaveri, Nurulain T.
Publicado em 2014

Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors

Por Zaveri, Nurulain T., Journigan, V. Blair, Polgar, Willma E.
Publicado no ACS Chem Neurosci (2015)

Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Agonists

Por Khroyan, Taline V., Polgar, Willma E., Jiang, Faming, Zaveri, Nurulain T., Toll, Lawrence
Publicado em 2009

High Affinity α3β4 Nicotinic Acetylcholine Receptor Ligands AT-1001 and AT-1012 Attenuate Cocaine-Induced Conditioned Place Preference and Behavioral Sensitization in Mice

Por Khroyan, Taline V., Yasuda, Dennis, Toll, Lawrence, Polgar, Willma E., Zaveri, Nurulain T.
Publicado no Biochem Pharmacol (2015)

Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/μ-Opioid Receptor Ligands: Implications for Therapeutic Applications

Por Toll, Lawrence, Khroyan, Taline V., Polgar, Willma E., Jiang, Faming, Olsen, Cris, Zaveri, Nurulain T.
Publicado em 2009

Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine

Por Cami-Kobeci, Gerta, Polgar, Willma E., Khroyan, Taline V, Toll, Lawrence, Husbands, Stephen M.
Publicado em 2011

Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: Potentiation of Morphine anti-allodynic activity by NOP receptor antagonists

Por Khroyan, Taline V., Polgar, Willma E., Orduna, Juan, Jiang, Faming, Olsen, Cris, Toll, Lawrence, Zaveri, Nurulain T.
Publicado em 2009

The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characteri...

Por Khroyan, Taline V., Polgar, Willma E., Cami-Kobeci, Gerta, Husbands, Stephen M., Zaveri, Nurulain T., Toll, Lawrence
Publicado em 2011

Differential Effects of Nociceptin/Orphanin FQ (NOP) Receptor Agonists in Acute versus Chronic Pain: Studies with Bifunctional NOP/μ Receptor Agonists in the Sciatic Nerve Ligation...

Por Khroyan, Taline V., Polgar, Willma E., Orduna, Juan, Montenegro, Jose, Jiang, Faming, Zaveri, Nurulain T., Toll, Lawrence
Publicado em 2011

[(125)I]AT-1012, a New High Affinity Radioligand for the α3β4 Nicotinic Acetylcholine Receptors

Por Wu, Jinhua, Perry, David C., Bupp, James E., Jiang, Faming, Polgar, Willma E., Toll, Lawrence, Zaveri, Nurulain T.
Publicado em 2013

In Vitro and In Vivo Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential

Por Khroyan, Taline V., Cippitelli, Andrea, Toll, Nicholas, Lawson, John A., Crossman, William, Polgar, Willma E., Toll, Lawrence
Publicado no Front Psychiatry (2017)

Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors

Por Zaveri, Nurulain, Polgar, Willma E., Olsen, Cris M., Kelson, Andrew B., Grundt, Peter, Lewis, John W., Toll, Lawrence
Publicado em 2001

AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats

Por Toll, Lawrence, Zaveri, Nurulain T, Polgar, Willma E, Jiang, Faming, Khroyan, Taline V, Zhou, Wei, Xie, Xinmin (Simon), Stauber, Gregory B, Costello, Matthew R, Leslie, Frances M
Publicado em 2012