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Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors
[Image: see text] The trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine scaffold is a known pharmacophore for mu opioid (MOP), kappa opioid (KOP), and delta opioid (DOP) receptor antagonists; however, it has not been explored in nociceptin opioid (NOP/ORL-1) receptor ligands. We recently found th...
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| Izdano u: | ACS Chem Neurosci |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2015
|
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4401318/ https://ncbi.nlm.nih.gov/pubmed/25635572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500367b |
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