Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors

[Image: see text] The trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine scaffold is a known pharmacophore for mu opioid (MOP), kappa opioid (KOP), and delta opioid (DOP) receptor antagonists; however, it has not been explored in nociceptin opioid (NOP/ORL-1) receptor ligands. We recently found th...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Neurosci
Asıl Yazarlar: Zaveri, Nurulain T., Journigan, V. Blair, Polgar, Willma E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2015
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401318/
https://ncbi.nlm.nih.gov/pubmed/25635572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn500367b
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