Differential Effects of Nociceptin/Orphanin FQ (NOP) Receptor Agonists in Acute versus Chronic Pain: Studies with Bifunctional NOP/μ Receptor Agonists in the Sciatic Nerve Ligation Chronic Pain Model in Mice

1-(1-Cyclooctylpiperidin-4-yl)-indolin-2-one (SR14150) and 1-(1-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)piperidinl-4-yl)-indolin-2-one (SR16835) are moderately selective nociceptin/orphanin FQ (NOP) receptor agonists. In the [(35)S]guanosine 5′-O-(3-thiotriphosphate) assay in vitro, SR14150 is a pa...

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Detalhes bibliográficos
Main Authors: Khroyan, Taline V., Polgar, Willma E., Orduna, Juan, Montenegro, Jose, Jiang, Faming, Zaveri, Nurulain T., Toll, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Behavioral Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199991/
https://ncbi.nlm.nih.gov/pubmed/21859931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.184663
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