AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats

Genomic and pharmacologic data have suggested the involvement of the α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) in drug seeking to nicotine and other drugs of abuse. In order to better examine this receptor subtype, we have identified and characterized the first high affinity and sel...

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Autores principales: Toll, Lawrence, Zaveri, Nurulain T, Polgar, Willma E, Jiang, Faming, Khroyan, Taline V, Zhou, Wei, Xie, Xinmin (Simon), Stauber, Gregory B, Costello, Matthew R, Leslie, Frances M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327842/
https://ncbi.nlm.nih.gov/pubmed/22278092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.322
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