Anti‐Parkinsonian and anti‐dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists

BACKGROUND AND PURPOSE: We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa‐induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two novel, potent and chemically distinct NOP recep...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Arcuri, Ludovico, Novello, Salvatore, Frassineti, Martina, Mercatelli, Daniela, Pisanò, Clarissa Anna, Morella, Ilaria, Fasano, Stefania, Journigan, Blair V, Meyer, Michael E, Polgar, Willma E, Brambilla, Riccardo, Zaveri, Nurulain T, Morari, Michele
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811622/
https://ncbi.nlm.nih.gov/pubmed/29232769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14123
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