Anti‐Parkinsonian and anti‐dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists

BACKGROUND AND PURPOSE: We previously showed that nociceptin/orphanin FQ opioid peptide (NOP) receptor agonists attenuate the expression of levodopa‐induced dyskinesia in animal models of Parkinson's disease. We now investigate the efficacy of two novel, potent and chemically distinct NOP recep...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Arcuri, Ludovico, Novello, Salvatore, Frassineti, Martina, Mercatelli, Daniela, Pisanò, Clarissa Anna, Morella, Ilaria, Fasano, Stefania, Journigan, Blair V, Meyer, Michael E, Polgar, Willma E, Brambilla, Riccardo, Zaveri, Nurulain T, Morari, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811622/
https://ncbi.nlm.nih.gov/pubmed/29232769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14123
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