In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations()

Nociceptin/Orphanin FQ (N/OFQ) regulates several biological functions via selective activation of the N/OFQ receptor (NOP). In this study novel nonpeptide NOP ligands were characterized in vitro in receptor binding and [(35)S]GTPγS stimulated binding in membranes of cells expressing human NOP and cl...

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Publicado no:Eur J Pharmacol
Main Authors: Ferrari, Federica, Cerlesi, Maria Camilla, Malfacini, Davide, Asth, Laila, Gavioli, Elaine C., Journigan, Blair V., Kamakolanu, Uma Gayathri, Meyer, Michael E., Yasuda, Dennis, Polgar, Willma E., Rizzi, Anna, Guerrini, Remo, Ruzza, Chiara, Zaveri, Nurulain T., Calo, Girolamo
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555400/
https://ncbi.nlm.nih.gov/pubmed/27780725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2016.10.025
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