In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations()

Nociceptin/Orphanin FQ (N/OFQ) regulates several biological functions via selective activation of the N/OFQ receptor (NOP). In this study novel nonpeptide NOP ligands were characterized in vitro in receptor binding and [(35)S]GTPγS stimulated binding in membranes of cells expressing human NOP and cl...

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Publicat a:Eur J Pharmacol
Autors principals: Ferrari, Federica, Cerlesi, Maria Camilla, Malfacini, Davide, Asth, Laila, Gavioli, Elaine C., Journigan, Blair V., Kamakolanu, Uma Gayathri, Meyer, Michael E., Yasuda, Dennis, Polgar, Willma E., Rizzi, Anna, Guerrini, Remo, Ruzza, Chiara, Zaveri, Nurulain T., Calo, Girolamo
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555400/
https://ncbi.nlm.nih.gov/pubmed/27780725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2016.10.025
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