Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

To investigate whether the endogenous neuropeptide nociceptin/orphanin FQ (N/OFQ) contributes to the death of dopamine neurons in Parkinson's disease, we undertook a genetic and a pharmacological approach using NOP receptor knockout (NOP(−/−)) mice, and the selective and potent small molecule N...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Arcuri, Ludovico, Viaro, Riccardo, Bido, Simone, Longo, Francesco, Calcagno, Mariangela, Fernagut, Pierre-Olivier, Zaveri, Nurulain T., Calò, Girolamo, Bezard, Erwan, Morari, Michele
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567676/
https://ncbi.nlm.nih.gov/pubmed/26804029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.01.016
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