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Modulation of Silent and Constitutively Active Nociceptin/Orphanin FQ Receptors by Potent Receptor Antagonists and Na(+) Ions in Rat Sympathetic Neurons

The pharmacology of G protein-coupled receptors can be influenced by factors such as constitutive receptor activation and Na(+) ions. In this study, we examined the coupling of natively and heterologously expressed nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptors with voltage-dependent Ca(2+)...

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Bibliographic Details
Main Authors: Mahmoud, Saifeldin, Margas, Wojciech, Trapella, Claudio, Caló, Girolamo, Ruiz-Velasco, Victor
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872970/
https://ncbi.nlm.nih.gov/pubmed/20159949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.062208
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