Opioid Bifunctional Ligands from Morphine and the Opioid Pharmacophore Dmt-Tic

Bifunctional ligands containing an ester linkage between morphine and the δ-selective pharmacophore Dmt-Tic were synthesized, and their binding affinity and functional bioactivity at the μ, δ and κ opioid receptors determined. Bifunctional ligands containing or not a spacer of β-alanine between the...

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Main Authors: Balboni, Gianfranco, Salvadori, Severo, Marczak, Ewa D., Knapp, Brian I., Bidlack, Jean M., Lazarus, Lawrence H., Peng, Xuemei, Si, Yu Gui, Neumeyer, John L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035428/
https://ncbi.nlm.nih.gov/pubmed/21216504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2010.12.001
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