Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action

The synthesis of new trimethoxybenzylidene–indolinones is reported. Their cytotoxic activity was evaluated according to Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD, drug screen protocols. The study of the mechanism of action suggests that inhibition of Nox4 in B1647 c...

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Detalhes bibliográficos
Main Authors: Andreani, Aldo, Granaiola, Massimiliano, Locatelli, Alessandra, Morigi, Rita, Rambaldi, Mirella, Varoli, Lucilla, Sega, Francesco Vieceli Dalla, Prata, Cecilia, Nguyen, Tam L., Bai, Ruoli, Hamel, Ernest
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712647/
https://ncbi.nlm.nih.gov/pubmed/23685944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.03.033
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