Optimization of GPR40 Agonists for Type 2 Diabetes

Por Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P., Dransfield, Paul J., Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R., Wong, Simon, Swaminath, Gayathri, Medina, Julio C., Lin, Daniel C.-H., Houze, Jonathan B.
Publicado em 2014

Synthesis of α-L-Rhamnosyl Ceramide and Evaluation of its Binding with Anti-Rhamnose Antibodies

Por Long, David E., Karmakar, Partha, Wall, Katherine A., Sucheck, Steven J.
Publicado em 2014

Potent s-cis-Locked Bithiazole Correctors of ΔF508 Cystic Fibrosis Transmembrance Conductance Regulator Cellular Processing for Cystic Fibrosis Therapy()

Por Yu, Gui Jun, Yoo, Choong L., Yang, Baoxue, Lodewyk, Michael W., Meng, Liping, El-Idreesy, Tamer T., Fettinger, James C., Tantillo, Dean J., Verkman, A. S., Kurth, Mark J.
Publicado em 2008

Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA)

Por Abdeen, Sanofar, Kunkle, Trent, Salim, Nilshad, Ray, Anne-Marie, Mammadova, Najiba, Summers, Corey, Stevens, Mckayla, Ambrose, Andrew J., Park, Yangshin, Schultz, Peter G., Horwich, Arthur L., Hoang, Quyen, Chapman, Eli, Johnson, Steven M.
Publicado no J Med Chem (2018)

Chemoinformatic expedition of the chemical space of fungal products

Por González-Medina, Mariana, Prieto-Martínez, Fernando D, Naveja, J Jesús, Méndez-Lucio, Oscar, El-Elimat, Tamam, Pearce, Cedric J, Oberlies, Nicholas H, Figueroa, Mario, Medina-Franco, José L
Publicado no Future Med Chem (2016)

Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polyme...

Por Talamas, Francisco X., Abbot, Sarah C., Anand, Shalini, Brameld, Ken A., Carter, David S., Chen, Jun, Davis, Dana, de Vicente, Javier, Fung, Amy D., Gong, Leyi, Harris, Seth F., Inbar, Petra, Labadie, Sharada S., Lee, Eun K., Lemoine, Remy, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, McIntosh, Joel, Nájera, Isabel, Park, Jaehyeon, Railkar, Aruna, Rajyaguru, Sonal, Sangi, Michael, Schoenfeld, Ryan C., Staben, Leanna R., Tan, Yunchou, Taygerly, Joshua P., Villaseñor, Armando G., Weller, Paul E.
Publicado em 2013

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

Por Hangeland, Jon J., Abell, Lynn M., Adam, Leonard P., Jiang, Ji, Friends, Todd J., Haque, Lauren E., Neels, James, Onorato, Joelle M., Chen, Alice Ye A., Taylor, David S., Yin, Xiaohong, Harrity, Thomas W., Basso, Michael D., Yang, Richard, Sleph, Paul G., Gordon, David A., Huang, Christine S., Wexler, Ruth R., Finlay, Heather J., Lawrence, R. Michael
Publicado no ACS Med Chem Lett (2018)

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

Por Zhang, Dong, Markoulides, Marios S., Stepanovs, Dmitrijs, Rydzik, Anna M., El-Hussein, Ahmed, Bon, Corentin, Kamps, Jos J.A.G., Umland, Klaus-Daniel, Collins, Patrick M., Cahill, Samuel T., Wang, David Y., von Delft, Frank, Brem, Jürgen, McDonough, Michael A., Schofield, Christopher J.
Publicado no Bioorg Med Chem (2018)

Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues

Por Fakhouri, Lara, El-Elimat, Tamam, Hurst, Dow P., Reggio, Patricia H., Pearce, Cedric J., Oberlies, Nicholas H., Croatt, Mitchell P.
Publicado no Bioorg Med Chem (2015)

Diarylcarbonates are a new class of deubiquitinating enzyme inhibitors

Por Long, Marcus J. C., Lawson, Ann P., Baggio, Rick, Qian, Yu, Rozhansky, Lior, Fasci, Domenico, Oualid, Farid El, Weerapana, Eranthie, Hedstrom, Lizbeth
Publicado no Bioorg Med Chem Lett (2018)

Evaluation of Phytocannabinoids from High Potency Cannabis sativa using In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid...

Por Husni, Afeef S., McCurdy, Christopher R., Radwan, Mohamed M., Ahmed, Safwat A., Slade, Desmond, Ross, Samir A., ElSohly, Mahmoud A., Cutler, Stephen J.
Publicado no Med Chem Res (2014)

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

Por Wan, Honghe, Schroeder, Gretchen M., Hart, Amy C., Inghrim, Jennifer, Grebinski, James, Tokarski, John S., Lorenzi, Matthew V., You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J., Trainor, George L., Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S., Khan, Javed A., Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K., Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N., Pragalathan, Bala, Narayanan, Sankara, K.C., Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V.
Publicado no ACS Med Chem Lett (2015)

Synthesis of Marine-Derived 3-Alkylpyridinium Alkaloids with Potent Antiprotozoal Activity

Por Rodenko, Boris, Al-Salabi, Mohammed I., Teka, Ibrahim A., Ho, William, El-Sabbagh, Nasser, Ali, Juma A. M., Ibrahim, Hasan M. S., Wanner, Martin J., Koomen, Gerrit-Jan, de Koning, Harry P.
Publicado em 2011

Exploration of Bivalent Ligands Targeting Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Dimerization

Por Arnatt, Christopher K., Falls, Bethany A., Yuan, Yunyun, Raborg, Thomas J., Masvekar, Ruturaj R., El-Hage, Nazira, Selley, Dana E., Nicola, Anthony V., Knapp, Pamela E., Hauser, Kurt F., Zhang, Yan
Publicado no Bioorg Med Chem (2016)

Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments

Por Skinner, Charles M., Miousse, Isabelle R., Ewing, Laura E., Sridharan, Vijayalakshmi, Cao, Maohua, Lin, Haixia, Williams, D. Keith, Avula, Bharathi, Haider, Saqlain, Chittiboyina, Amar G., Khan, Ikhlas A., ElSohly, Mahmoud A., Boerma, Marjan, Gurley, Bill J., Koturbash, Igor
Publicado no Food Chem Toxicol (2018)

Hydrolytic Reactivity Trends among Potential Prodrugs of the O(2)-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity

Por Valdez, Carlos A., Saavedra, Joseph E., Showalter, Brett M., Davies, Keith M., Wilde, Thomas C., Citro, Michael L., Barchi, Joseph J., Deschamps, Jeffrey R., Parrish, Damon, El-Gayar, Stefan, Schleicher, Ulrike, Bogdan, Christian, Keefer, Larry K.
Publicado em 2008

Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid

Por Charbon, Godefroid, Wang, Jiangyun, Brustad, Eric, Schultz, Peter G., Horwich, Arthur L., Jacobs-Wagner, Christine, Chapman, Eli
Publicado em 2011

Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl-Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

Por Stec, Jozef, Fomovska, Alina, Afanador, Gustavo A., Muench, Stephen P., Zhou, Ying, Lai, Bo-Shiun, Bissati, Kamal El, Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Sommervile, Caroline, Woods, Stuart, Roberts, Craig W., Rice, David, Prigge, Sean T., McLeod, Rima, Kozikowski, Alan P.
Publicado em 2013

A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL

Por Chapman, Eli, Farr, George W., Furtak, Krystyna, Horwich, Arthur L.
Publicado em 2008

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase

Por Johnson, James A., Tora, George, Pi, Zulan, Phillips, Monique, Yin, Xiaohong, Yang, Richard, Zhao, Lei, Chen, Alice Y., Taylor, David S., Basso, Michael, Rose, Anne, Behnia, Kamelia, Onorato, Joelle, Chen, Xue-Qing, Abell, Lynn M., Lu, Hao, Locke, Gregory, Caporuscio, Christian, Galella, Michael, Adam, Leonard P., Gordon, David, Wexler, Ruth R., Finlay, Heather J.
Publicado no ACS Med Chem Lett (2018)