Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues

(5Z)-7-Oxozeanol and related analogues were isolated and screened to explore their activity as TAK1 inhibitors. Seven analogues were synthesized and more than a score of natural products isolated that examined the role that different areas of the molecule contribute to TAK1 inhibition. A novel nonar...

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Publicat a:Bioorg Med Chem
Autors principals: Fakhouri, Lara, El-Elimat, Tamam, Hurst, Dow P., Reggio, Patricia H., Pearce, Cedric J., Oberlies, Nicholas H., Croatt, Mitchell P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661079/
https://ncbi.nlm.nih.gov/pubmed/26481152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.09.037
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