Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis

Resorcylic acid lactones (RALs) with a cis-enone moiety, represented by hypothemycin (1) and (5Z)-7-oxozeaenol (2), are fungal secondary metabolites with irreversible inhibitory activity against protein kinases, with particularly selective activity for inhibition of TAK1 (transforming growth factor...

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Detalhes bibliográficos
Publicado no:J Antibiot (Tokyo)
Main Authors: Al Subeh, Zeinab Y., Raja, Huzefa A., Obike, Jennifer C., Pearce, Cedric J., Croatt, Mitchell P., Oberlies, Nicholas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313427/
https://ncbi.nlm.nih.gov/pubmed/34155352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-021-00432-3
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