Semisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle

Silymarin, an extract of the seeds of milk thistle (Silybum marianum), is used as an herbal remedy, particularly for hepatoprotection. The main chemical constituents in silymarin are seven flavonolignans. Recent studies explored the non-selective methylation of one flavonolignan, silybin B, and then...

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Главные авторы: Althagafy, Hanan S., Graf, Tyler N., Sy-Cordero, Arlene A., Gufford, Brandon T., Paine, Mary F., Wagoner, Jessica, Polyak, Stephen J., Croatt, Mitchell P., Oberlies, Nicholas H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855444/
https://ncbi.nlm.nih.gov/pubmed/23673225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.017
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