Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions

Silybum marianum (L.) Gaertn. (Asteraceae), commonly known as milk thistle, is a botanical natural product used to self-treat multiple diseases such as type 2 diabetes mellitus and nonalcoholic steatohepatitis (NASH). An extract from milk thistle seeds (achenes), termed silymarin, is comprised prima...

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Veröffentlicht in:Phytother Res
Hauptverfasser: Lynch, Katherine D., Montonye, Michelle L., Tian, Dan-Dan, Arman, Tarana, Oyanna, Victoria O., Bechtold, Baron J., Graf, Tyler N., Oberlies, Nicholas H., Paine, Mary F., Clarke, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217340/
https://ncbi.nlm.nih.gov/pubmed/33587330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ptr.7049
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