Broad-Spectrum Anti-Cancer Activity of O(2)-Arylated Diazeniumdiolates

Por Keefer, Larry K.
Publicado em 2010

Fifty Years of Diazeniumdiolate Research. From Laboratory Curiosity to Broad-Spectrum Biomedical Advances

Por Keefer, Larry K.
Publicado em 2011

Unexpected Incorporation of Bromine at a Non-anomeric Position during the Synthesis of an O(2)-Glycosylated Diazeniumdiolate

Por Saavedra, Joseph E., Davies, Keith M., Barchi, Joseph J., Keefer, Larry K.
Publicado em 2009

Differential effects of nitric oxide on blood–brain barrier integrity and cerebral blood flow in intracerebral C6 gliomas

Por Weyerbrock, Astrid, Walbridge, Stuart, Saavedra, Joseph E., Keefer, Larry K., Oldfield, Edward H.
Publicado em 2011

Diazeniumdiolated carbamates: A novel class of nitric oxide donors

Por Nandurdikar, Rahul S., Maciag, Anna E., Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2012

Decoding Nitric Oxide Release Rates of Amine-Based Diazeniumdiolates

Por Wang, Yan-Ni, Collins, Jack, Holland, Ryan J., Keefer, Larry K., Ivanic, Joseph
Publicado em 2013

The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis

Por Qu, Wei, Liu, Jie, Fuquay, Richard, Saavedra, Joseph E., Keefer, Larry K., Waalkes, Michael P.
Publicado em 2007

Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase

Por Holland, Ryan J., Paulisch, Rika, Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E., Donzelli, Sonia
Publicado em 2013

Aryl bis(Diazeniumdiolates): Potent Inducers of S-Glutathionylation of Cellular Proteins and Their in Vitro Anti-Proliferative Activities

Por Andrei, Daniela, Maciag, Anna E., Chakrapani, Harinath, Citro, Michael L., Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2008

V-PROLI/NO, a Nitric Oxide Donor Prodrug, Protects Liver Cells from Arsenic-Induced Toxicity

Por Qu, Wei, Liu, Jie, Dill, Anna L., Saavedra, Joseph E., Keefer, Larry K., Waalkes, Michael P.
Publicado em 2008

O(2)-Acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): Synthesis, nitric oxide release, and biological evaluation studies

Por Velázquez, Carlos A., Rao, P.N. Praveen, Citro, Michael L., Keefer, Larry K., Knaus, Edward E.
Publicado em 2007

Synthesis, Nitric Oxide Release, and Anti-Leukemic Activity of Glutathione-Activated Nitric Oxide Prodrugs: Structural Analogues of PABA/NO, an Anti-Cancer Lead Compound

Por Chakrapani, Harinath, Wilde, Thomas C., Citro, Michael L., Goodblatt, Michael M., Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2007

Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class

Por Maciag, Anna E., Holland, Ryan J., Saavedra, Joseph E., Chakrapani, Harinath, Shami, Paul J., Keefer, Larry K.
Publicado em 2012

Direct Reaction of Amides with Nitric Oxide To Form Diazeniumdiolates

Por Holland, Ryan J., Klose, John R., Deschamps, Jeffrey R., Cao, Zhao, Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2014

Synthesis and In Vitro Anti-Leukemic Activity of Structural Analogues of JS-K, an Anti-Cancer Lead Compound

Por Chakrapani, Harinath, Goodblatt, Michael M., Udupi, Vidya, Malaviya, Swati, Shami, Paul J., Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2008

Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O(2)-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, An...

Por Chattopadhyay, Mitali, Velazquez, Carlos A., Pruski, April, Nia, Kamran V., Abdellatif, Khaled R., Keefer, Larry K., Kashfi, Khosrow
Publicado em 2010

Aminolysis of an N-Diazeniumdiolated Amidine as an Approach to Diazeniumdiolated Ammonia

Por Biswas, Debanjan, Hrabie, Joseph A., Saavedra, Joseph E., Cao, Zhao, Keefer, Larry K., Ivanic, Joseph, Holland, Ryan J.
Publicado em 2014

Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs

Por Chakrapani, Harinath, Kalathur, Ravi C., Maciag, Anna E., Citro, Michael L., Ji, Xinhua, Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2008

Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound

Por Nandurdikar, Rahul S., Maciag, Anna E., Citro, Michael L., Shami, Paul J., Keefer, Larry K., Saavedra, Joseph E., Chakrapani, Harinath
Publicado em 2009

Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs

Por Nandurdikar, Rahul S., Maciag, Anna E., Hong, Sam Y., Chakrapani, Harinath, Citro, Michael L., Keefer, Larry K., Saavedra, Joseph E.
Publicado em 2010