Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound

Here we report a number of novel JS-K structural analogues with sub-micromolar anti-proliferative activities against human leukemia cell lines HL-60 and U937; JS-K is the anti-cancer lead compound O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate. The ability of t...

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Main Authors: Nandurdikar, Rahul S., Maciag, Anna E., Citro, Michael L., Shami, Paul J., Keefer, Larry K., Saavedra, Joseph E., Chakrapani, Harinath
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755573/
https://ncbi.nlm.nih.gov/pubmed/19364650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.115
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