Synthesis, Nitric Oxide Release, and Anti-Leukemic Activity of Glutathione-Activated Nitric Oxide Prodrugs: Structural Analogues of PABA/NO, an Anti-Cancer Lead Compound

Diazeniumdiolate anions and their prodrug forms are reliable sources of nitric oxide (NO) that have generated interest as promising therapeutic agents. A number of structural analogues of O(2)-(2,4-dinitro-5-(4-(N-methylamino)benzoyloxy)phenyl) 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate (PABA/NO)...

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Autores principales: Chakrapani, Harinath, Wilde, Thomas C., Citro, Michael L., Goodblatt, Michael M., Keefer, Larry K., Saavedra, Joseph E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631658/
https://ncbi.nlm.nih.gov/pubmed/18060792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.11.035
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