Differential effects of nitric oxide on blood–brain barrier integrity and cerebral blood flow in intracerebral C6 gliomas

Nitric oxide (NO) signaling in tumors and endothelial cells regulates vascular permeability and blood flow and therefore influences tumor uptake and response to therapeutic compounds. As delivery and efficacy of chemotherapy is impaired in CNS neoplasms due to a partially intact blood–brain barrier...

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Bibliographic Details
Main Authors: Weyerbrock, Astrid, Walbridge, Stuart, Saavedra, Joseph E., Keefer, Larry K., Oldfield, Edward H.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064621/
https://ncbi.nlm.nih.gov/pubmed/21041233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq161
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