Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π activated nitric oxide donor PABA/NO in malignant gliomas

Glutathione-S-transferases (GST) are upregulated in malignant gliomas and contribute to their chemoresistance. The nitric oxide (NO) donor PABA/NO generates NO upon selective enzymatic activation by GST-π inducing selective biological effects in tumors. Tumor cell killing and chemosensitization were...

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Main Authors: Kogias, Evangelos, Osterberg, Nadja, Baumer, Brunhilde, Psarras, Nikolaos, Koentges, Christoph, Papazoglou, Anna, Saavedra, Joseph E, Keefer, Larry K, Weyerbrock, Astrid
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161158/
https://ncbi.nlm.nih.gov/pubmed/21455987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.26106
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