Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI

Nitric oxide (NO) released from NO donors can be cytotoxic in tumor cells and can enhance the transport of drugs into brain tumors by altering blood-tumor barrier permeability. The NO donor JS-K [O(2)-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] releases NO upon...

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Main Authors: Weidensteiner, Claudia, Reichardt, Wilfried, Shami, Paul J., Saavedra, Joseph E., Keefer, Larry K., Baumer, Brunhilde, Werres, Anna, Jasinski, Robert, Osterberg, Nadja, Weyerbrock, Astrid
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617040/
https://ncbi.nlm.nih.gov/pubmed/23370169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.niox.2013.01.003
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