JS-K, an arylating nitric oxide (NO) donor, has synergistic anti-leukemic activity with cytarabine (ARA-C)

We have designed prodrugs that release NO on metabolism by Glutathione S-Transferases (GST). This design exploits the upregulation of GST in Acute Myeloid Leukemia (AML) cells. O(2)-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl] diazen-1-ium-1,2-diolate (JS-K, a member of this class) has p...

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Main Authors: Shami, Paul J., Maciag, Anna E., Eddington, Jordan K., Udupi, Vidya, Kosak, Ken M., Saavedra, Joseph E., Keefer, Larry K.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756046/
https://ncbi.nlm.nih.gov/pubmed/19193435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2009.01.002
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