Potent s-cis-Locked Bithiazole Correctors of ΔF508 Cystic Fibrosis Transmembrance Conductance Regulator Cellular Processing for Cystic Fibrosis Therapy()

N-(5-(2-(5-Chloro-2-methoxyphenylamino)thiazol-4-yl)-4-methylthiazol-2-yl)pivalamide 1 (compound 15Jf) was found previously to correct defective cellular processing of the cystic fibrosis protein ΔF508-CFTR. Eight C4′-C5 C,C-bond-controlling bithiazole analogs of 1 were designed, synthesized, and ev...

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Hlavní autoři: Yu, Gui Jun, Yoo, Choong L., Yang, Baoxue, Lodewyk, Michael W., Meng, Liping, El-Idreesy, Tamer T., Fettinger, James C., Tantillo, Dean J., Verkman, A. S., Kurth, Mark J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167067/
https://ncbi.nlm.nih.gov/pubmed/18788728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800533c
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