Structure-Activity Relationships of Cyanoquinolines with Corrector-Potentiator Activity in delta-F508-Cystic Fibrosis Transmembrane Conductance Regulator Protein

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The most common CF-causing mutation, ΔF508-CFTR, produces CFTR loss-of-function by impairing its cellular targeting to the plasma membrane and its chloride channel gating....

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Main Authors: Knapp, John M., Wood, Alex B., Phuan, Puay-Wah, Lodewyk, Michael W., Tantillo, Dean J., Verkman, A. S., Kurth, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277286/
https://ncbi.nlm.nih.gov/pubmed/22214395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201372q
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