Fluorinated ΔF508-CFTR Correctors and Potentiators for PET Imaging

(19)F-modified bithiazole correctors and phenylglycine potentiators of the ΔF508-CFTR chloride channnels were synthesized and their function assayed in cells expressing human ΔF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups f...

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Main Authors: Davison, Holly R., Solano, Danielle M., Phuan, Puay-Wah, Verkman, A. S., Kurth, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274619/
https://ncbi.nlm.nih.gov/pubmed/22281185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.12.128
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