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Fluorinated ΔF508-CFTR Correctors and Potentiators for PET Imaging
(19)F-modified bithiazole correctors and phenylglycine potentiators of the ΔF508-CFTR chloride channnels were synthesized and their function assayed in cells expressing human ΔF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups f...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3274619/ https://ncbi.nlm.nih.gov/pubmed/22281185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.12.128 |
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