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Potentiators of Defective ΔF508–CFTR Gating that Do Not Interfere with Corrector Action

Combination drug therapies under development for cystic fibrosis caused by the ∆F508 mutation in cystic fibrosis transmembrane conductance regulator (CFTR) include a “corrector” to improve its cellular processing and a “potentiator” to improve its chloride channel function. Recently, it was reported...

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Bibliografiska uppgifter
I publikationen:Mol Pharmacol
Huvudupphovsmän: Phuan, Puay-Wah, Veit, Guido, Tan, Joseph A., Finkbeiner, Walter E., Lukacs, Gergely L., Verkman, A. S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576684/
https://ncbi.nlm.nih.gov/pubmed/26245207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099689
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